Discovery Projects - Grant ID: DP0342760

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0342760

Funding Status
Closed

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Funded Activity Summary

Characterization of erythroid differentiation related factor (EDRF): a novel a-globin binding protein. Hemoglobin, a four-subunit protein comprising two alpha and two beta polypeptide chains, is the essential oxygen transporter found in all mammals. Problems with the synthesis of hemoglobin can give rise to a range of common and serious human disorders, including thalassaemia and anemia. We have discovered a protein, EDRF, that appears to interact directly with alpha-globin (but not beta-globin) and to play a role in the regulation of hemoglobin production. We now seek to understand the nature of this interaction at a molecular level and mechanistic level.

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $579,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry: Proteins And Peptides | Biochemistry and Cell Biology | Analytical Biochemistry |

ANZSRC Socio-Economic Objective (SEO)

Blood disorders | Biological sciences

Other Keywords

Analytical Biochemistry | Biochemistry and Cell Biology | Biological sciences | Blood disorders | Medical Biochemistry: Proteins And Peptides

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