Discovery Projects - Grant ID: DP0342596

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0342596

Funding Status
Closed

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Funded Activity Summary

Molecular Basis for the Mitochondrial Stress Response. The biogenesis of mitochondria depends on the co-ordinated expression of mitochondrial and nuclear genomes. Little is known about the extent and how the expression of both cellular genomes is co-ordinated. We have discovered a novel biological process, the mitochondrial stress response, whereby the establishment of stress within the mitochondria results in the upregulation of a suite of genes in the nucleus encoding proteins which rescue mitochondria from damage caused by stress. This project is to determine how stress is sensed in the mitochondrion and communicated to the nucleus resulting in alterations in gene expression. The project also aims to define the physiological role of mitochondrial chaperones in protein folding in the organelle.

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-01-2006

Funding Scheme: Discovery Projects

Funding Amount: $330,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Protein Targeting And Signal Transduction

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