Discovery Projects - Grant ID: DP0342581

Funded Activity Summary

Early evolutionary origins of mechanosensory transduction: structure, function and phylogenetic studies of the family of mechanosensitive channels in cell-walled organisms. The proposed project is based on the recent progress the applicants have made by (i) identifying a novel family of mechanosensitive (MS) channels in cell-walled organisms, which include Archaea and Bacteria (prokaryotes), as well as fungi and plants (eukaryotes), and (ii) determining basic aspects of the structural dynamics of MscL, the prototype MS channel, using electronparamagnetic resonance spectroscopy and molecular dynamics simulations in combination with the patch clamp technique. The aim of the project is to elucidate the molecular principles underlying the function of MS channels, which is of fundamental importance for understanding of the biophysics and physiology of mechanosensory transduction throughout the biological world.

Funded Activity Details

Start Date: 01-01-2005

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $580,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biological Sciences Not Elsewhere Classified | Other Biological Sciences | Microbiology Not Elsewhere Classified | Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

International relations not elsewhere classified | Higher education | Biological sciences |

Other Keywords

Biological Sciences Not Elsewhere Classified | Biological sciences | Higher education | International relations not elsewhere classified | Membrane Biology | Microbiology Not Elsewhere Classified | Other Biological Sciences

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