Discovery Projects - Grant ID: DP0342458

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0342458

Funding Status
Closed

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Funded Activity Summary

The role of fatty acid binding proteins in the binding and transport of lipophilic drugs. Poorly water-soluble drugs must cross the aqueous cytoplasm of intestinal cells if they are to be absorbed following oral administration. The mechanisms by which this occurs are currently unknown. We have shown that some lipophilic drugs are capable of binding to cytosolic transport proteins called fatty acid binding proteins (FABPs). We propose to use a range of physical techniques including NMR spectroscopy, calorimetry and fluorescence firstly to identify the nature of drug binding to FABP and secondly to determine the effect of binding on drug transport.

Funded Activity Details

Start Date: 01-01-2003

End Date: 30-06-2006

Funding Scheme: Discovery Projects

Funding Amount: $255,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified | Pharmaceutical Sciences And Pharmacy | Macromolecular and Materials Chemistry | Physical Chemistry Of Macromolecules

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Biological sciences |

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biological sciences | Macromolecular and Materials Chemistry | Pharmaceutical Sciences And Pharmacy | Physical Chemistry Of Macromolecules | Treatments (e.g. chemicals, antibiotics)

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