Discovery Projects - Grant ID: DP0212064

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0212064

Funding Status
Closed

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Funded Activity Summary

Investigation of the biochemical and physiological functions of the negative regulator of cytokine signalling SOCS-2. Cytokines exert their effects by binding and signalling through specific cell surface receptors to elicit their biological action, and if left unchecked, this signalling can cause significant tissue damage and toxicity. Our aim is to characterise a novel regulator of cytokine signalling, SOCS-2. SOCS-2 is strongly implicated in the regulation of post-natal growth as SOCS-2 deficient animals are 40 percent larger than normal. Consequently, we wish to determine how SOCS-2 acts to limit the size of an animal and whether this involves regulation of growth hormone action.

Funded Activity Details

Start Date: 01-01-2002

End Date: 31-12-2004

Funding Scheme: Discovery Projects

Funding Amount: $187,118.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Physiology—Systems | Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Animal Growth And Development

ANZSRC Socio-Economic Objective (SEO)

Livestock not elsewhere classified | Endocrine organs and diseases (incl. diabetes) |

Other Keywords

Animal Growth And Development | Animal Physiology—Systems | Biochemistry and Cell Biology | Endocrine organs and diseases (incl. diabetes) | Livestock not elsewhere classified | Protein Targeting And Signal Transduction

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