Discovery Projects - Grant ID: DP0211703

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0211703

Funding Status
Closed

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Funded Activity Summary

Biosynthesis of nonribosomal peptide toxins in cyanobacteria: A functional characterisation of microcystin synthetase. Microcystins are potent toxins and tumour promoters produced by cyanobacteria associated with blue-green algal blooms. This non-ribosomal peptide is produced by microcystin synthetase, a unique enzyme complex comprised of peptide synthetases, polyketide synthases, and integrated accessory enzymes. We have identified and characterised the extensive gene cluster encoding this enzyme. This project describes the biochemical characterisation of specific enzyme activities within microcystin synthetase and how they determine the final structure and toxicity of the many forms of microcystin. Interactions between this enzyme complex and its substrate amino acids will provide information for the genetic engineering of this and similar natural products.

Funded Activity Details

Start Date: 01-02-2002

End Date: 30-06-2005

Funding Scheme: Discovery Projects

Funding Amount: $175,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Genetic Engineering And Enzyme Technology | Biochemistry and Cell Biology | Gene Expression

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Enzymes | Gene Expression | Genetic Engineering And Enzyme Technology | Treatments (e.g. chemicals, antibiotics)

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