Discovery Projects - Grant ID: DP0211334

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0211334

Funding Status
Closed

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Funded Activity Summary

A Gas Phase Study of Macromolecular Biological Complexes. Following the completion of the human genome project, increased attention has focussed on the elucidation of structure and function of biopolymers in cells. The project aims to use electrospray ionisation mass spectrometry (a rapidly developing analytical technique) to detail the processes governing the formation of macromolecular complexes (DNA-protein and DNA-metal-protein) in the gas phase. We aim to explore the relevance of gas phase studies of these large macromolecular complexes to interactions between biopolymers in solution and cells. Ultimately, this will aid in the development of improved therapeutics tha t act on DNA and/or DNA-binding proteins and provide new information on biological processes such as replicaton.

Funded Activity Details

Start Date: 05-10-2004

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $220,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Other Instrumental Methods | Medicinal and Biomolecular Chemistry | Biological And Medical Chemistry | Analytical Biochemistry |

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Cancer and related disorders | Chemical sciences

Other Keywords

Analytical Biochemistry | Biological And Medical Chemistry | Cancer and related disorders | Chemical sciences | Medicinal and Biomolecular Chemistry | Other Instrumental Methods | Treatments (e.g. chemicals, antibiotics)

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