Discovery Projects - Grant ID: DP0211310

Funded Activity Summary

How does clusterin protect cells from stresses? We recently discovered that clusterin: (i) is the only known secreted (ie extracellular) mammalian chaperone and (ii) can protect proteins and cells from stresses.These breakthrough advances provide the first unifying biological function for this protein - in whole organisms, clusterine is likely to protect tissues and organs form biologyical stresses. The work proposed will provide quantum advances in our understanding of the molecular basis by which clusterin effects its protective actions. We expect to demonstrate that clusterin protects cells form stresses by exerting its chaperone action at or near the cell surface and to identify specific regions and structural features of the clusterine molecule important in its chaperone action.

Funded Activity Details

Start Date: 01-02-2002

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $140,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

Clinical health not specific to particular organs, diseases and conditions | Biological sciences |

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Clinical health not specific to particular organs, diseases and conditions | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Membrane Biology

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