Discovery Projects - Grant ID: DP0211215

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0211215

Funding Status
Closed

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Funded Activity Summary

Synthetic derivatives of capsaicin and gingerols as analgesics acting at the vanilloid receptor. This project aims to prepare alpha-hydroxyketones and gingerol derivatives acting at vanilloid (VR1) receptor with potential analgesic activity. These compounds will be tested for their ability to activate the VR1 receptor, desensitize the receptor and release neuropeptides associated with pain pathways. The development of these novel compounds will contribute towards understanding the mechanisms of VR1 receptor activation and provide information on how the VR1 receptor is regulated. We will determine and compare neurotoxicity of these compounds to capsaicin which is known to possess neurotoxic activity. The outcome of this project may result in effective agents for better pain management.

Funded Activity Details

Start Date: 15-01-2002

End Date: 14-01-2005

Funding Scheme: Discovery Projects

Funding Amount: $155,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sensory Systems | Pharmacology and Pharmaceutical Sciences | Pharmaceutical Sciences And Pharmacy | Protein Targeting And Signal Transduction |

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Biological sciences | Chemical sciences

Other Keywords

Biological sciences | Chemical sciences | Nervous system and disorders | Pharmaceutical Sciences And Pharmacy | Pharmacology and Pharmaceutical Sciences | Protein Targeting And Signal Transduction | Sensory Systems

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