Discovery Projects - Grant ID: DP0210598

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0210598

Funding Status
Closed

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Funded Activity Summary

Macrocyclic Peptidomimetics. Proteins and peptides are among the most exquisite examples of hosts/guests for molecular recognition. Composed of amino acid building blocks, peptides are highly flexible and structurally promiscuous, switching between multiple structures (random/strand/sheet/turn/helical) in solution. Peptides pay a significant entropy penalty to organize into the one structure recognised by a biological receptor and responsible for activity. We are developing new macrocycles, composed of molecular constraints and amino acids, organized into specific strand, turn, or helical shapes. These building blocks are more structured, more chemically stable, and have higher receptor affinities than peptides enabling potential uses as new biological tools, drug leads, catalysts, devices or new materials.

Funded Activity Details

Start Date: 01-01-2002

End Date: 31-12-2006

Funding Scheme: Discovery Projects

Funding Amount: $1,550,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological And Medical Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Biological sciences | Chemical sciences

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological And Medical Chemistry | Biological sciences | Chemical sciences | Enzymes | Treatments (e.g. chemicals, antibiotics)

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