Discovery Projects - Grant ID: DP0210511

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0210511

Funding Status
Closed

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Funded Activity Summary

Second messenger-activated calcium channels in liver cells. This project concerns second messenger-activated calcium channels, part of the family of hormone-activated calcium channels which are essential to the functions of all animal cells. The aims are to elucidate the properties of a novel "large conductance" Ca2+ channel (using maitotoxin as an artificial activator), an inositol 1,4,5-trisphosphate-activated calcium channel, and the calcium channel formed by the transient receptor potential-1 (TRP-1) protein in hepatocytes. The electrophysiological properties, mechanisms of activation and intracellular trafficking of the channels will be investigated. It is anticipated the results will provide basic information on the physiological functions of second messenger-activated calcium channels. This will benefit the understanding of liver function, hepatotoxicity in animals, animal production and the development of pharmaceuticals in animal husbandary.

Funded Activity Details

Start Date: 01-01-2002

End Date: 13-12-2004

Funding Scheme: Discovery Projects

Funding Amount: $140,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

Sheep—meat | Treatments (e.g. chemicals, antibiotics) |

Other Keywords

Biochemistry and Cell Biology | Membrane Biology | Protein Targeting And Signal Transduction | Sheep—meat | Treatments (e.g. chemicals, antibiotics)

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