Discovery Projects - Grant ID: DP0210330

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0210330

Funding Status
Closed

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Funded Activity Summary

Metal Clips for Folding Peptides. Large protein molecules fold into shapes that are important for their function. These shapes are defined by secondary structures stabilised by hydrogen bonds, packing effects, and sometimes also by the binding of metal ions. Smaller peptides corresponding to these secondary structures tend to adopt only random structures in solution, away from the stabilising environment of the protein. In this project metal ions are used to clip together components of small peptides, thereby stabilising secondary structures (alpha helices) identical to those adopted by proteins. Small peptides so constrained may reproduce some properties of proteins, such as interactions with biological receptors.

Funded Activity Details

Start Date: 01-01-2002

End Date: 31-12-2004

Funding Scheme: Discovery Projects

Funding Amount: $300,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Bioinorganic Chemistry | Biochemistry And Cell Biology Not Elsewhere Classified | Inorganic Chemistry | Transition Metal Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Chemical sciences

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Bioinorganic Chemistry | Biological sciences | Chemical sciences | Inorganic Chemistry | Transition Metal Chemistry

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