Discovery Projects - Grant ID: DP0209570

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0209570

Funding Status
Closed

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Funded Activity Summary

Biological Role of Contraction-Induced Heat Shock Protein Expression. It is well known that mammalian skeletal muscle increases its expression of a group of highly conserved proteins, the heat shock proteins (HSP) in response to repeated contraction. However, the biological role of this expression is unclear. The aim of this project is to determine the biological role of contraction-induced HSP expression. We expect to show that HSP synthesis in response to exercise has three major roles; 1) to act to repair damaged proteins in recovery from muscle injury 2) to act as a "molecular motor" to translocate proteins from one region of a muscle cell to another and 3) to be released into the circulation in order to act as a central signal to activate immune cells. Such a project will be significant because it will allow for a fundamental understanding as to why these proteins are produced in response to exercise. We expect to enhance our understanding of fundamental cell biology.

Funded Activity Details

Start Date: 01-01-2002

End Date: 20-09-2005

Funding Scheme: Discovery Projects

Funding Amount: $140,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Human Movement and Sports Science | Cell Metabolism | Exercise Physiology

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

Other Keywords

Biological sciences | Cell Metabolism | Exercise Physiology | Human Movement and Sports Science

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