Discovery Projects - Grant ID: DP0209273

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0209273

Funding Status
Closed

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Funded Activity Summary

Understanding and changing the mechanism of an enzyme: converting a peptidase to a phosphotriesterase. Enzymes have the ability to catalyse biological reactions rapidly as a consequence of their unique three-dimensional structures. We seek to define the structures of a family of metalloenzymes that are required in most living organisms to activate hormones, degrade unwanted proteins or recycle the protein building blocks for further synthesis. We shall use this information to enhance a second function of these enzymes, namely their ability to break down organophosphorus-containing insecticides and nerve agents. Ultimately, the structural information resulting from this project may be used in drug design to regulate blood pressure and in engineering proteins for bioremediation.

Funded Activity Details

Start Date: 01-01-2002

End Date: 31-12-2004

Funding Scheme: Discovery Projects

Funding Amount: $242,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Bioinorganic Chemistry | Biochemistry and Cell Biology |

ANZSRC Socio-Economic Objective (SEO)

Agricultural chemicals | Biological sciences

Other Keywords

Agricultural chemicals | Biochemistry and Cell Biology | Bioinorganic Chemistry | Biological sciences | Enzymes | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc.

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