Discovery Projects - Grant ID: DP0208857

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0208857

Funding Status
Closed

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Funded Activity Summary

Shaping a signal: studies on non-contiguous residues in an intracellular serpin that constitute a novel nuclear protein import signal. Eukaryotic cells contain membrane-bound organelles like the nucleus, endoplasmic reticulum and mitochondria, and use specific mechanisms to direct proteins from their site of synthesis to their target organelle. In nuclear proteins, sequence motifs termed nuclear localization signals (NLSs) direct engagement with the nuclear pore complex and translocation from cytoplasm to nucleus. All NLSs described so far consist of 5-7 contiguous basic residues. We propose to study a novel NLS that we recently discovered on an intracellular serpin. This comprises non-contiguous residues that together form a basic "patch" on the mature protein, and is the first example of a conformational NLS.

Funded Activity Details

Start Date: 01-01-2002

End Date: 31-12-2004

Funding Scheme: Discovery Projects

Funding Amount: $180,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Protein Targeting And Signal Transduction

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