Discovery Projects - Grant ID: DP0208320

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0208320

Funding Status
Closed

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Funded Activity Summary

Structural studies of catalysis and electron transfer by copper proteins. We propose to determine the crystal structures of five copper-containing proteins. Three are amine oxidases, enzymes that protect a wide range of organisms against toxic cell products (amines). Novel chemical modifications and crystallographic techniques will be used to test hypotheses for the enzyme mechanism. The results will provide a basis for the future manipulation of the enzymes' activities. Our other targets, sulfocyanin and auracyanin-A, perform essential electron-transfer functions in an archaeon and a photosynthetic bacterium, respectively. The determination of their molecular structures will answer exciting questions about electron transfer in primitive organisms, and about the evolution of copper proteins as biological electron-transfer agents.

Funded Activity Details

Start Date: 01-01-2002

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $270,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Bioinorganic Chemistry | Inorganic Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Chemical sciences

Other Keywords

Bioinorganic Chemistry | Biological sciences | Chemical sciences | Enzymes | Inorganic Chemistry

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