Discovery Projects - Grant ID: DP0208282

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0208282

Funding Status
Closed

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Funded Activity Summary

Function and regulation of the Na+,K+-ATPase. The Na+,K+-ATPase is the major energy-consuming enzyme of animal cells. Its ion pumping is essential for numerous physiological functions (e.g. heart, kidney, brain). Molecular detail of its pumping mechanism is, however, lacking and its regulation is still unclear. We will use rapid reaction methods on purified enzyme in vitro to locate the rate-determining step of the enzyme cycle, determine its mechanism, investigate its regulation by sodium concentration, phosphorylation and membrane composition, and isolate its charge-transporting steps. The results will have immediate impact on the understanding of the enzyme's mechanism, its metabolic control and its role in disease.

Funded Activity Details

Start Date: 03-01-2002

End Date: 28-02-2005

Funding Scheme: Discovery Projects

Funding Amount: $141,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Membrane Biology | Mechanisms Of Reactions

ANZSRC Socio-Economic Objective (SEO)

Urogenital system and disorders | Cardiovascular system and diseases | Nutrition |

Other Keywords

Biochemistry and Cell Biology | Cardiovascular system and diseases | Enzymes | Mechanisms Of Reactions | Membrane Biology | Nutrition | Urogenital system and disorders

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