Discovery Projects - Grant ID: DP0208186

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0208186

Funding Status
Closed

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Funded Activity Summary

The Application of Chemical Force Microscopy for Monitoring DNA Hybridization: A New Sensing Concept Capable of Detecting Single Molecules. This proposal outlines a method of monitoring DNA sequences with such high sensitivity that a single molecule may be detected. Such sensitivity is achieved using an atomic force microscope (AFM) to measure surface forces. Modifying an AFM tip with a single strand of DNA allows the complementary strand (the target) to be recognized via hybridization to form the double helix. The occurrence of hybridization is determined by differences in surface force measurements compared with when only the single strand of DNA is present. In this way DNA samples can be analyzed without amplification; a major advance for DNA diagnostics.

Funded Activity Details

Start Date: 01-06-2002

End Date: 31-12-2003

Funding Scheme: Discovery Projects

Funding Amount: $50,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Analytical Biochemistry | Colloid And Surface Chemistry | Sensor (Chemical And Bio-) Technology | Physical Chemistry (Incl. Structural)

ANZSRC Socio-Economic Objective (SEO)

Diagnostic methods | Scientific instrumentation |

Other Keywords

Analytical Biochemistry | Colloid And Surface Chemistry | Diagnostic methods | Physical Chemistry (Incl. Structural) | Scientific instrumentation | Sensor (Chemical And Bio-) Technology

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