Discovery Projects - Grant ID: DP0208033

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0208033

Funding Status
Closed

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Funded Activity Summary

Probing JNK MAPK function with peptide inhibitors. It has generally been accepted that the JNK MAPK family of protein kinases is rapidly and potently activated following the exposure of mammalian cells to stresses and cytokines. However, their biological role has remained controversial. We believe that this problem reflects the lack of a generally applicable and specific JNK MAPK inhibitor. In this project we continue our characterisation of a small peptide inhibitor developed in our laboratories. We aim to determine its mechanism of inhibition, the specificity of interaction, and to evolve more effective inhibitors. With these new inhibitors, we can effectively address the biological roles of these kinases.

Funded Activity Details

Start Date: 25-01-2002

End Date: 24-01-2005

Funding Scheme: Discovery Projects

Funding Amount: $141,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Molecular Evolution | Biochemistry and Cell Biology | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Clinical health not specific to particular organs, diseases and conditions | Treatments (e.g. chemicals, antibiotics) | Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Clinical health not specific to particular organs, diseases and conditions | Enzymes | Molecular Evolution | Protein Targeting And Signal Transduction | Treatments (e.g. chemicals, antibiotics)

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