Discovery Early Career Researcher Award - Grant ID: DE240101286

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE240101286

Funding Status
Active

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Funded Activity Summary

SARS-CoV-2-induced dead cell fragments drive viral uptake and inflammation. This project will apply advanced cell biology and imaging techniques to investigate how macrophages, which lacks a canonical receptor for viral entry, become infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and elicit inflammatory responses. Its insights into a novel pathway of viral entry is expected to advance our understanding of host-pathogen interaction. The project is intended to uncover the role of SARS-CoV-2-induced dead cell fragmentation in promoting viral uptake and inflammation. Its findings should provide significant scientific, health and economic benefits by informing new research directions on infection and innate immunity as well as future therapeutic designs for infection treatment.

Funded Activity Details

Start Date: 01-01-2024

End Date: 07-02-2024

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $469,707.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal cell and molecular biology | Infectious agents | Biochemistry and cell biology | Cell development proliferation and death |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Animal cell and molecular biology | Biochemistry and cell biology | Cell development proliferation and death | Expanding Knowledge In the Biological Sciences | Infectious agents

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