Discovery Early Career Researcher Award - Grant ID: DE240101055

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE240101055

Funding Status
Active

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Funded Activity Summary

How blood vessel stiffness regulates their growth and maintenance. This project aims to reveal an unidentified molecular mechanism of how endothelial cells in the walls of blood vessels detect stiffness of the surrounding environment in order to regulate blood vessel growth and maintenance. The results are expected to advance the emerging field of mechanobiology by combining cutting-edge cell biology and microscopy techniques carried out in novel 3D cell culture and unique quail models. The benefits of these outcomes include generation of knowledge on the impact of tissue stiffness on the signalling mechanisms that drive formation and maintenance of blood vessels. In the long term, this fundamental understanding could give rise to major developments in emerging industries such as organ bioengineering.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $448,737.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and cell biology | Signal transduction | Receptors and membrane biology | Mechanobiology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Expanding Knowledge In the Biological Sciences | Mechanobiology | Receptors and membrane biology | Signal transduction

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