Discovery Early Career Researcher Award - Grant ID: DE240100992

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE240100992

Funding Status
Active

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Funded Activity Summary

New methods to capture protein dynamics of the TSC-mTOR signalling axis. Protein flexibility, the way proteins move, has a major role in how they function. However, we still do not have the tools to analyse this flexibility. Our cells have evolved many complex and flexible systems to sense and respond to their environment. For example, the TSC-mTOR system is found across life, from baker’s yeast to humans, however it remains poorly understood. This proposal will study TSC as an exemplar to develop novel machine-learning approaches to capture protein flexibility and shape. This proposal will advance fundamental understanding of the TSC-mTOR pathway and build transformative methodologies to study flexible proteins more broadly.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $448,237.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and cell biology | Structural biology (incl. macromolecular modelling) | Molecular imaging (incl. electron microscopy and neutron diffraction)

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Application Software Packages | Biochemistry and cell biology | Expanding Knowledge In the Biological Sciences | Molecular imaging (incl. electron microscopy and neutron diffraction) | Structural biology (incl. macromolecular modelling)

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