Discovery Early Career Researcher Award - Grant ID: DE240100931

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE240100931

Funding Status
Active

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Funded Activity Summary

Molecular insights into the allosteric regulation of opioid receptors. Allosteric regulation is the biological process by which molecules bind to proteins someplace other than their active site, regulating their activity. Proteins on the cell surface called membrane receptors can be allosterically regulated to fine-tune the response of cells to the environment. This project aims to investigate how small molecules regulate receptor activity at a molecular level, using opioid receptors as an exemplar system. I will use an interdisciplinary approach that combines structural biology, medicinal chemistry, analytical pharmacology, and cell biology. The knowledge gained from these studies will advance fundamental understanding of receptor function and can lay the foundation for future drug discovery efforts.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $453,237.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and cell biology | Basic pharmacology | Structural biology (incl. macromolecular modelling) | Receptors and membrane biology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Basic pharmacology | Biochemistry and cell biology | Expanding Knowledge In the Biological Sciences | Expanding Knowledge In the Chemical Sciences | Receptors and membrane biology | Structural biology (incl. macromolecular modelling)

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