Discovery Early Career Researcher Award - Grant ID: DE240100793

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE240100793

Funding Status
Declined

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Funded Activity Summary

Unraveling a new cytokine working model in immune cell exhaustion. This project will investigate a novel paradigm of how a key messenger protein can be sensed by fundamental immune cells, preventing their ‘exhaustion’. Immune cell exhaustion is a fundamental mechanism to maintain the internal homeostasis of vertebrates. However, it is often hijacked by pathogens to dampen the defensive capacity of the immune system. And this specific messenger protein is the only known soluble factor that can deliver ‘anti-exhaustion’ signals to immune cells. This study will advance basic knowledge in biochemistry and immunology by combining interdisciplinary and cutting-edge approaches. The expected outcomes include the developing new scientific theories and identifying novel molecular basis of biological processes.

Funded Activity Details

Start Date: Start date not available

End Date: End date not available

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $463,180.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular immunology | Biochemistry and cell biology | Structural biology (incl. macromolecular modelling) | Receptors and membrane biology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Cellular immunology | Expanding Knowledge In the Biological Sciences | Receptors and membrane biology | Structural biology (incl. macromolecular modelling)

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