Discovery Early Career Researcher Award - Grant ID: DE240100780

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE240100780

Funding Status
Active

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Funded Activity Summary

Functional and structural dissection of the human replisome. This project aims to develop technology to visualise the structure and enzymatic activities of the human replisome, the multiprotein assembly that copies DNA before cell division. A combination of novel single-molecule and state-of-the-art cryo-electron microscopy will be used to define how the human replisome coordinates DNA synthesis during times of replication stress. Key outcomes of this project include development of novel molecular visualisation technologies, leading to the first molecular description of dynamic processes used by the human replisome. Benefits include improved understanding of a fundamental biological process that often malfunctions in cancers, development of novel methodology, and interdisciplinary training.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $455,237.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of biological macromolecules | Enzymes | Biochemistry and cell biology | Structural biology (incl. macromolecular modelling) |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Characterisation of biological macromolecules | Enzymes | Expanding Knowledge In the Biological Sciences | Human Pharmaceutical Treatments | Structural biology (incl. macromolecular modelling)

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