Discovery Early Career Researcher Award - Grant ID: DE240100707

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE240100707

Funding Status
Active

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Funded Activity Summary

Towards a molecular fingerprint for human-specific endogenous retroviruses. This project aims to understand how ancient viral sequences resident in the human genome can contribute to cellular processes. Using a novel molecular toolbox that combines affinity-directed proximity labelling mass spectrometry and single molecule microscopy, this project will characterise the cellular fingerprint of a human endogenous retrovirus family HERV-K (HML-2). This fingerprint will comprehensively describe how expressed HERV-K loci engage with the homeostasis network in human cells. This will provide significant benefits in the form of new knowledge concerning fundamental aspects of cellular homeostasis, and a state-of-the-art molecular biology toolbox ready to explore quantitatively the role of HERV-K in human health and disease.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $450,926.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and intermolecular interactions (excl. medical proteomics) | Protein trafficking | Biochemistry and cell biology | Cell development proliferation and death |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Cell development proliferation and death | Expanding Knowledge In the Biological Sciences | Expanding Knowledge In the Biomedical and Clinical Sciences | Protein trafficking | Proteomics and intermolecular interactions (excl. medical proteomics)

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