Discovery Early Career Researcher Award - Grant ID: DE230101315

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE230101315

Funding Status
Active

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Funded Activity Summary

The dynamic interplay between the matrix and cell fate in developing heart. Malformations in the developing heart can lead to catastrophic defects and embryonic loss. The valves play a critical role in blood flow regulation and are made of a stratified matrix that is laid down early in development. This project aims to determine how the cellular fate of the early valve cells establish the layered matrix and in turn how the matrix can influence cell fate by utilising a multi-omics approach to identify unique cell populations and integrate transcriptional and protein changes during matrix disruption. This project expects to generate fundamental knowledge on how matrix structure can influence cell fate in the valves and will advance Australia's knowledge base and research capabilities in developmental biology.

Funded Activity Details

Start Date: 01-01-2023

End Date: 31-12-2025

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $461,154.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal cell and molecular biology | Developmental genetics (incl. sex determination) | Cell development proliferation and death | Genetics |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Animal cell and molecular biology | Cell development proliferation and death | Developmental genetics (incl. sex determination) | Expanding Knowledge In the Biological Sciences | Genetics

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