Discovery Early Career Researcher Award - Grant ID: DE230101173

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE230101173

Funding Status
Active

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Funded Activity Summary

Inhibiting adenylate-forming enzymes via a new reaction-hijacking mechanism. This project aims to identify and validate the adenylate-forming enzymes that are susceptible to reaction-hijacking inhibition in malaria parasites. This class of enzymes can be induced to synthesise their own nucleoside sulfamate inhibitor conjugates via a novel mechanism. This project expects to provide new knowledge about the molecular basis of this novel inhibition mechanism and susceptible target enzymes in the parasites. Adenylate-forming enzymes play critical roles in a diverse range of biochemical pathways, such as protein translation and fatty acid metabolism. The project seeks to deliver a new paradigm for the design of future antiparasitic agents.

Funded Activity Details

Start Date: 01-01-2023

End Date: 31-12-2025

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $374,318.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and intermolecular interactions (excl. medical proteomics) | Enzymes | Biochemistry and cell biology |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Enzymes | Proteomics and intermolecular interactions (excl. medical proteomics) | Public Health (Excl. Specific Population Health) Not Elsewhere Classified

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