Discovery Early Career Researcher Award - Grant ID: DE230100837

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE230100837

Funding Status
Active

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Funded Activity Summary

Modulating protein phase behavior: cell functions vs material development. It has been recognized recently that cellular proteins can undergo liquid-liquid phase separation, however, a further liquid-to-solid transition can lead to aberrant biological processes. This project aims to investigate and control this behaviour to gain insights into cell dysfunction and new routes for biomaterials development. An integrated approach combining microfluidic platforms, optical techniques, and vibrational spectroscopy will be exploited. Expected outcomes of this project include the mechanistic understanding of protein phase behaviour and protein-based biomaterial engineering. This should provide significant benefits in the prevention of aberrant protein aggregation and the generation of materials as plastic substitutes.

Funded Activity Details

Start Date: 16-10-2023

End Date: 15-10-2026

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $441,454.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and cell biology | Microfluidics and nanofluidics | Structural biology (incl. macromolecular modelling) |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Expanding Knowledge In Engineering | Expanding Knowledge In the Biological Sciences | Microfluidics and nanofluidics | Structural biology (incl. macromolecular modelling)

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