Discovery Early Career Researcher Award - Grant ID: DE230100084

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE230100084

Funding Status
Active

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Funded Activity Summary

Deciphering the rules of T cell residency across intestinal compartments. Tissue-resident memory T cells (TRM) are key for immune protection against infection and cancer at barrier sites including the gut. Whilst much of our understanding of gut TRM comes from studies on the small intestine, how these cells develop and function in the large intestine is unknown. Using state-of-the-art techniques and novel animal models, this project aims to (i) identify molecular pathways by which the local intestinal microenvironment influences TRM development and (ii) how these pathways could modulate TRM generation specifically in the small or large intestine. The expected outcomes are to generate fundamental new knowledge that will have significance for regulation of the immune response.

Funded Activity Details

Start Date: 01-01-2023

End Date: 31-12-2025

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $471,754.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular immunology | Cell development proliferation and death | Immunology | Infectious diseases

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Cell development proliferation and death | Cellular immunology | Expanding Knowledge In the Biological Sciences | Immunology | Infectious diseases

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