Discovery Early Career Researcher Award - Grant ID: DE220101424

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE220101424

Funding Status
Closed

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Funded Activity Summary

Molecular basis of Prestin’s electromotility and sound discrimination . Sonar animals like whales can hear at exceptionally high frequencies allowing them to echolocate. Humans, though, can hear at much higher frequencies than reptiles and birds. Frequency sensing mainly depends on a protein in the ear called Prestin. Currently, the structure and working mechanism of Prestin is unknown. This project aims to characterize how Prestin responds to high frequencies by probing the electro-mechanical force generated using mechanically gated channels as a reporter. Single particle cryo-electron microscopy will also be used to visualize Prestin’s 3D structure. Together, this DECRA project will elucidate the molecular basis of hearing differences across species and reshapes our understanding of the evolution of hearing.

Funded Activity Details

Start Date: 31-12-2022

End Date: 31-12-2022

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $434,282.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Hearing, Vision, Speech and Their Disorders | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Hearing, Vision, Speech and Their Disorders | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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