Discovery Early Career Researcher Award - Grant ID: DE220101210

Funded Activity Summary

Deciphering molecular genetic mechanisms underlying chromatin interactions. This project aims to generate the high confidence map of enhancer-promoter links in 61 tissues and cells through robust integration of novel machine learning tools with genomic and epigenomic datasets. Understanding which key elements in the genome may be important to fine-tune gene expression is essential for understanding biological pathways. The expected outcomes include i) New tools to robustly identify true chromatin pairs; ii) Comperehensive maps of regulatory interactomes in 61 tissues & cells, which will provide a roadmap for interpreting & prioritising noncoding variants. This should provide significant benefit to Australia's capacity for cutting-edge genomics research through fundamental understanding of gene regulation mechanism.

Funded Activity Details

Start Date: 01-04-2023

End Date: 31-03-2026

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $451,634.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genome Structure and Regulation | Pattern Recognition and Data Mining | Genetics | Quantitative Genetics (incl. Disease and Trait Mapping Genetics)

ANZSRC Socio-Economic Objective (SEO)

Human Biological Preventatives (e.g. Vaccines) | Expanding Knowledge in the Biological Sciences | Computer Software and Services not elsewhere classified |

Other Keywords

Computer Software and Services not elsewhere classified | Expanding Knowledge in the Biological Sciences | Genetics | Genome Structure and Regulation | Human Biological Preventatives (e.g. Vaccines) | Pattern Recognition and Data Mining | Quantitative Genetics (incl. Disease and Trait Mapping Genetics)

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