Discovery Early Career Researcher Award - Grant ID: DE220100830

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE220100830

Funding Status
Active

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Funded Activity Summary

Elucidating the genesis of MAIT cell-mediated immunity. T cells develop in the thymus and proceed to survey our body probing molecules that signal if anything is abnormal. A specialised subset of T cells, mucosal associated invariant T (MAIT) cells are crucial in detecting microbial molecules and infection, yet their numbers vary widely between individuals. A key problem is that the factors controlling their development and function are poorly understood. This proposal aims to decode this critical issue in MAIT cell biology, using innovative tools to investigate the molecular basis underpinning their development in the thymus. This work will provide vital, fundamental discoveries into how MAIT cells are produced and regulated, as we ultimately wish to harness MAIT cells to improve human health.

Funded Activity Details

Start Date: 30-12-2022

End Date: 30-12-2025

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $464,928.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Receptors and Membrane Biology | Immunology | Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Immune System and Allergy |

Other Keywords

Cell Development, Proliferation and Death | Cellular Immunology | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Immunology | Receptors and Membrane Biology

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