Discovery Early Career Researcher Award - Grant ID: DE200101511

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE200101511

Funding Status
Active

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Structural insights into activation, dynamics and bias of GPCRs. The project aims to investigate the mechanisms underlying activation, biased agonism and G protein selectivity of G protein-coupled receptors (GPCRs) by utilising the adenosine A1 receptor as a model system. This project expects to generate knowledge in the area of GPCR biology using an interdisciplinary approach including structural biology, pharmacology, biochemistry and protein engineering. The expected outcomes include (i) understanding the structural mechanisms underlying GPCR activation, (ii) biased agonism and (iii) G protein selectivity. This should provide significant benefits, such as advancement of fundamental knowledge in GPCR biology and pharmacology that could also one day lead to therapeutic development.

Funded Activity Details

Start Date: 10-02-2020

End Date: 09-02-2023

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $424,816.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular System and Diseases | Neurodegenerative Disorders Related to Ageing | Cancer and Related Disorders |

Other Keywords

Biochemistry and Cell Biology | Cancer and Related Disorders | Cardiovascular System and Diseases | Neurodegenerative Disorders Related to Ageing | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

Related Links