Discovery Early Career Researcher Award - Grant ID: DE200101300

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE200101300

Funding Status
Active

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Funded Activity Summary

Lipopolysaccharide-induced macrophage extracellular traps in host defence. The innate immune system is the first line of defence against invading microbes. Macrophages are key innate immune cells that deploy antimicrobial responses to clear infection and restore health. There are many critical unanswered questions on the molecular mechanisms that drive macrophage inflammatory and antimicrobial pathways. This project aims to elucidate a novel inflammatory mechanism that immobilises and kills invading bacteria via newly discovered structures made by dying macrophages called extracellular traps. Insight we gain by interrogating this immune cell signalling pathway, called the non-canonical inflammasome, will add valuable knowledge to our fundamental understanding of mammalian inflammation and anti-microbial responses

Funded Activity Details

Start Date: 13-01-2020

End Date: 31-12-2023

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $423,711.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Agents | Immunology | Signal Transduction | Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Expanding Knowledge in the Biological Sciences | Immunology | Infectious Agents | Innate Immunity | Signal Transduction

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