Discovery Early Career Researcher Award - Grant ID: DE190100668

Funded Activity Summary

Cysteamine dioxygenases: novel oxygen sensors implicated in hypoxia? This project aims to characterise and manipulate a novel oxygen sensing system, the cysteamine dioxygenases, to help understand how mammalian cells respond to low oxygen concentrations, a condition known as hypoxia. A number of the world’s most destructive diseases can impair oxygen delivery, altering biochemical landscapes. By understanding how cells respond to fluctuations in oxygen, the project expects to develop effective methods to treat these detrimental conditions. Characterisation of the cysteamine dioxygenases could establish a novel mechanism by which cells monitor changes in oxygen, assisting in understanding hypoxia and disease. The project will also enable new cysteine initiating substrates to be identified, allowing the full impact of this regulatory process to be appreciated in mammals.

Funded Activity Details

Start Date: 27-05-2019

End Date: 31-12-2022

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $422,574.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Molecular Targets | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular System and Diseases | Cancer and Related Disorders | Expanding Knowledge in the Biological Sciences |

Other Keywords

Cancer and Related Disorders | Cardiovascular System and Diseases | Characterisation of Biological Macromolecules | Enzymes | Expanding Knowledge in the Biological Sciences | Medicinal and Biomolecular Chemistry | Molecular Targets

Related Links