Discovery Early Career Researcher Award - Grant ID: DE190100609

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE190100609

Funding Status
Closed

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Funded Activity Summary

Mechanobiology: a new model of integrin activation by membrane tension. This project aims to address a fundamental question in mechanobiology on how integrin receptor coordinates with force to mediate cell spreading, migration, growth and survival. With an observation that membrane deformation enhances integrin binding, the project expects to establish a new model of integrin activation by membrane tension. It will develop an integrated approach combining single-molecule force probes, super resolution microscopy, microfluidics and molecular dynamics simulations. It is expected that the role of membrane tension in promoting cell adhesion will be defined at molecular scale, and the link between integrin activation and Piezo calcium channel mediated membrane tension sensing will be delineated.

Funded Activity Details

Start Date: 01-07-2019

End Date: 30-06-2022

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $368,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Receptors and Membrane Biology | Biomechanical Engineering

ANZSRC Socio-Economic Objective (SEO)

Scientific Instruments | Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Biomechanical Engineering | Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences | Receptors and Membrane Biology | Scientific Instruments

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