Discovery Early Career Researcher Award - Grant ID: DE190100304

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE190100304

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Understanding intramolecular regulation of ubiquitin enzymes. This project aims to combine structural, biophysical and functional studies to characterise how ubiquitin enzymes are regulated. Ubiquitination controls essential cellular pathways in all eukaryotes and this project expects to generate new knowledge regarding the vital regulation of this process. This project expects to develop broadly applicable techniques for investigating protein conformation and self-association as a means of controlling catalytic activity. The project should significantly increase understanding of several modes of regulation of ubiquitin ligase catalytic activity, and how this controls a myriad of cellular processes. The project will lay the foundation for applied research anti-viral compounds, plant anti-fungals and cancer therapies.

Funded Activity Details

Start Date: 01-01-2019

End Date: 25-09-2020

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $416,092.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Characterisation of Biological Macromolecules | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Infectious Diseases

Other Keywords

Biochemistry and Cell Biology | Characterisation of Biological Macromolecules | Enzymes | Expanding Knowledge in the Biological Sciences | Infectious Diseases | Structural Biology (incl. Macromolecular Modelling)

Related Links