Discovery Early Career Researcher Award - Grant ID: DE180100929

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE180100929

Funding Status
Closed

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Funded Activity Summary

Stronger together: understanding antibiotic synergy on a molecular level. This project aims to use genomics-based approaches to answer fundamental questions about how antibiotic synergy works. Antibiotic combination therapy presents an opportunity to revive the use of antibiotics in otherwise resistant bacteria, yet currently there is little understanding of the molecular mechanisms underlying antibiotic synergy. Studies indicate that additional mechanisms of action (MOA) occur during synergistic killing beyond those of the original antibiotics. This project will identify genes involved in multiple synergistic treatments and determine how bacterial cells gain resistance. The synergy-specific MOA identified also represent an untapped reservoir of primary drug targets.

Funded Activity Details

Start Date: 03-12-2018

End Date: 03-12-2022

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $365,058.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Microbial Genetics | Microbiology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) |

Other Keywords

Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Microbial Genetics | Microbiology

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