Discovery Early Career Researcher Award - Grant ID: DE170100783

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE170100783

Funding Status
Closed

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Funded Activity Summary

Structural basis of paramyxovirus host cell entry. This project aims to investigate interactions between paramyxoviruses and host cell receptors and the mechanisms underlying fusion activation at a molecular level. Paramyxoviruses include economically important human and animal pathogens. Two viral proteins are key to infection: an attachment protein for the interaction with host receptors, and a fusion protein for fusion of viral and cellular membranes. The project is anticipated to discover general principles of how paramyxoviruses infect host cells, which should advance fundamental understanding of viral infection strategies and may identify strategies for rational design of inhibitors targeting host-cell entry of multiple paramyxoviruses.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-12-2019

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $372,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Virology | Characterisation of Biological Macromolecules | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Characterisation of Biological Macromolecules | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Structural Biology (incl. Macromolecular Modelling) | Virology

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