Discovery Early Career Researcher Award - Grant ID: DE170100628

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE170100628

Funding Status
Closed

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Funded Activity Summary

Promotion of NAD+ anabolism to promote lifespan. The project aims to identify mechanisms of ageing, the role of stress on the ageing brain and how NAD+ modulates these effects. NAD+ maintains cellular energy, repairs DNA and performs other essential cell functions. Intracellular NAD+ levels, the essential substrate for sirtuin activity including SIRT2, decline with age in humans and physiologically aged rats. This project will investigate the mechanisms by which pharmacological strategies designed to elevate intracellular NAD+ levels will maintain optimal SIRT2 function to extend lifespan and improve age-related cognitive decline in vivo. Potential outcomes include using NAD+ to improve brain health in advanced old age.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-12-2019

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $372,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System | Public Nutrition Intervention | Neurosciences

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Health Status (e.g. Indicators of Well-Being) |

Other Keywords

Central Nervous System | Expanding Knowledge in the Biological Sciences | Health Status (e.g. Indicators of Well-Being) | Neurosciences | Public Nutrition Intervention

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