Discovery Early Career Researcher Award - Grant ID: DE170100575

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE170100575

Funding Status
Closed

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Funded Activity Summary

Pathogen detection in mammals. This project aims to study the role of a host molecule in immune protection. Multicellular organisms need to recognise pathogens to initiate immune protection. To do this, pathogen-specific molecules are presented to the immune system causing activation. Recently a mode of pathogen recognition was discovered in mammals. As microbes synthesise essential vitamins, they release tell-tale metabolite by-products, which a host molecule called MR1 captures and presents to white blood cells. However, it is not understood how MR1 accomplishes this, the cellular machinery required, or how the metabolites are guided to MR1. Understanding this process is expected to explain microbial pathogen recognition.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-03-2020

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $372,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Agents | Protein Trafficking | Biochemistry and Cell Biology | Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Infectious Agents | Protein Trafficking | Receptors and Membrane Biology

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