Discovery Early Career Researcher Award - Grant ID: DE170100315

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE170100315

Funding Status
Closed

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Funded Activity Summary

Combinatorial design of multivalent polymers for cell receptor clustering. This project aims to design biologically active multivalent peptide-polymer conjugates. This project will use an enzyme to conduct the reactions in tiny volumes in the open air, and prepare and screen large libraries of different architectures for their ability to kill cancer cell lines through the clustering of death receptor proteins on the cell surface. Such combinatorial techniques have been crucial to the development of small molecule drugs. This project aims to apply this technique to well-defined macromolecules, studying their structure-activity relationships, and could lead ultimately to the generation of lead compounds for therapeutics with high commercial relevance.

Funded Activity Details

Start Date: 01-01-2017

End Date: 30-06-2020

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $360,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Macromolecular and Materials Chemistry | Synthesis of Materials | Biomaterials

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences |

Other Keywords

Biomaterials | Expanding Knowledge in the Chemical Sciences | Macromolecular and Materials Chemistry | Synthesis of Materials

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