Discovery Early Career Researcher Award - Grant ID: DE170100239

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE170100239

Funding Status
Closed

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Funded Activity Summary

The molecular basis of endothelial mechanotransduction through TRPV4. This project aims to understand how blood flow dynamics coordinate the plasma membrane localisation and interaction of the transient receptor potential vanilloid 4 (TRPV4), a candidate mechanosensitive ion channel broadly expressed in endothelium with physiological and pathological roles in the cardiovascular system, with other mechanoreceptors and the physiological relevance of these events. Blood flow haemodynamics affect cardiovascular health and morphogenesis. This project will highlight the role of TRPV4 channels in the short- and long-term adaptive responses to shear stress and will also have significant potential for application in future drug discovery.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-12-2020

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $372,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Biochemistry and Cell Biology | Receptors and Membrane Biology | Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Expanding Knowledge in the Biological Sciences | Receptors and Membrane Biology | Signal Transduction

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