Discovery Early Career Researcher Award - Grant ID: DE170100152

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE170100152

Funding Status
Closed

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Funded Activity Summary

Molecular insight into allosteric modulation of G protein-coupled receptors. The project aims to understand the molecular mechanisms underlying signal transduction and allosteric modulation of G protein-coupled receptors (GPCRs). Allosteric modulation of proteins is a fundamental process where two distinctly different binding sites are linked through a conformational change. This project will use structural biology, medicinal chemistry and analytical pharmacology to investigate how chemical probes modulate GPCRs at an atomic level, and understand the mechanisms underlying signal transduction. Project outcomes are intended to advance membrane protein crystallography and GPCR biology, and benefit the pharmaceutical industry.

Funded Activity Details

Start Date: 01-01-2017

End Date: 31-12-2019

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $372,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Nervous System and Disorders | Neurodegenerative Disorders Related to Ageing |

Other Keywords

Biochemistry and Cell Biology | Nervous System and Disorders | Neurodegenerative Disorders Related to Ageing | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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