Discovery Early Career Researcher Award - Grant ID: DE170100058

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE170100058

Funding Status
Closed

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Funded Activity Summary

Molecular reporters for measuring proteostasis capacity in cells. This project aims to develop fluorescent dyes to report on the change in unfolded protein load, which reflects the proteostasis status in real time in cells under stress conditions. Proteostasis is a housekeeping process cells undertake to maintain the proper folding and functions of proteins. Perturbation of proteostasis has been linked to neurodegenerative diseases, but chemical probes cannot measure the proteostasis capacity in cells. Intended outcomes include a mechanistic understanding of the relationship between protein misfolding, aggregation and proteostasis. This is expected to ultimately benefit the diagnosis of protein folding diseases, including dementia, and improve the quality of life.

Funded Activity Details

Start Date: 01-02-2017

End Date: 31-08-2020

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $372,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Analytical Biochemistry | Biologically Active Molecules | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Analytical Biochemistry | Biochemistry and Cell Biology | Biologically Active Molecules | Cell Metabolism | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences

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