Discovery Early Career Researcher Award - Grant ID: DE160101142

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE160101142

Funding Status
Closed

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Funded Activity Summary

Unravelling the structural evolution of centipede toxins. The project intends to improve understanding of venom evolution in centipedes, and uncover new families of peptides with potential application in the agrochemical and pharmaceutical sectors. Venoms have emerged as a rich source of pharmacological tools with potential for development into therapeutics and bioinsecticides. However, venoms-based discovery has been limited by the narrow taxonomical range studied, and many groups of venomous animals remain overlooked. One such group is centipedes, whose venoms contain diverse novel toxins. This project aims to provide an insight into centipede toxin evolution, and establish a structure-based approach to understanding their evolution and structural diversification. The outcomes may contribute to our understanding of protein evolution and support the development of new products.

Funded Activity Details

Start Date: 01-01-2016

End Date: 03-01-2019

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $360,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Molecular Evolution | Structural Biology (incl. Macromolecular Modelling) | Genetics

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Products not elsewhere classified | Control of Pests, Diseases and Exotic Species not elsewhere classified | Expanding Knowledge in the Biological Sciences |

Other Keywords

Control of Pests, Diseases and Exotic Species not elsewhere classified | Expanding Knowledge in the Biological Sciences | Genetics | Human Pharmaceutical Products not elsewhere classified | Molecular Evolution | Proteins and Peptides | Structural Biology (incl. Macromolecular Modelling)

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