Discovery Early Career Researcher Award - Grant ID: DE160100608

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE160100608

Funding Status
Closed

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Funded Activity Summary

Investigating the structural basis of human antibody stability. This project plans to use protein engineering and X-ray crystallography to investigate the effects of stabilising mutations on antigen binding and the antibody-antigen interaction. Monoclonal antibodies are high-affinity reagents that have transformed the study of biological processes. However, antibodies often display inherent instability, which limits applicability. Mutations have recently been identified that render human antibodies resistant to aggregation. Preliminary data indicates that stabilising mutations improves the biophysical properties of monoclonals without affecting the native antibody structure. The project aims to provide detailed insights into the molecular basis of antibody stability.

Funded Activity Details

Start Date: 31-03-2016

End Date: 18-01-2019

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $359,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Synthetic Biology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Structural Biology (incl. Macromolecular Modelling) | Synthetic Biology

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