Discovery Early Career Researcher Award - Grant ID: DE160100293

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE160100293

Funding Status
Declined

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Funded Activity Summary

Cracking the phosphoinositide code. This project seeks to determine how protein interactions with membrane lipids regulate recruitment to cellular organelles, providing new insight into the complex pathways of cellular homeostasis. Controlling the distribution of proteins within cells is critical for cell signalling and membrane trafficking. This is orchestrated by the interaction of specific protein modules with lipids on the surface of different organelles. The phox homology (PX) domain is a lipid-binding module found in numerous proteins essential for normal cell trafficking and homeostasis, and perturbed in many conditions including immune dysfunction and cancer. This project plans to investigate molecular determinants of PX-lipid association, generating knowledge about protein-membrane interactions required for cellular function. These insights may underpin future drug design.

Funded Activity Details

Start Date: Start date not available

End Date: End date not available

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $372,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking | Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Protein Trafficking | Structural Biology (incl. Macromolecular Modelling)

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