Discovery Early Career Researcher Award - Grant ID: DE160100282

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DE160100282

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Mechanotransduction within the Immune Synapse. This project plans to use advanced microscopy to study the forces involved in T-cell activation which lead to an immune response. T-cells readily detect the presence of even a single antigenic peptide-major histocompatibility complex (pMHC) and discriminate among thousands of endogenous pMHC via T-cell receptors (TCRs) on the surface of antigen-presenting cells. The mechanisms underlying this phenomenal sensitivity have remained elusive, but more recent studies suggest mechanical forces to be instrumental. To investigate their role, the project plans to introduce force sensors into the immune synapse. Understanding the molecular mechanisms could provide new approaches to improving adoptive immunotherapy and to generating new hypotheses for drug development and targeting.

Funded Activity Details

Start Date: 01-01-2016

End Date: 30-11-2017

Funding Scheme: Discovery Early Career Researcher Award

Funding Amount: $377,500.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Biochemistry and Cell Biology | Receptors and Membrane Biology | Signal Transduction |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Biochemistry and Cell Biology | Cellular Immunology | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Receptors and Membrane Biology | Signal Transduction

Related Links